Evaluation of the Efficacy of IALUSET VITAL® Cream in Helping the Improvement of the Atopic Dermatitis Symptoms in Adults: A Randomized, Double Blind, Vehicle-Controlled Clinical Trial

Atopic dermatitis (AD) is a chronic relapsing skin disease, associated with impaired barrier function and characterized by poorly defined pruritic, erythematous lesions. In this study, the efficacy of new topical cream (IALUSET VITAL®), containing hyaluronic acid extract Salvia haenkei, in reducing symptoms moderate AD adults was investigated. This study randomized, double blind, vehicle-controlled clinical study. Treatment evaluated considering both objective parameters (Scoring Dermatitis, SCORAD) subjective pa-rameters (Patient Oriented Eczema Measure, POEM, an itching sensation) through non-invasive bioengineering techniques to measure moisturization Trans Epidermal Water Loss (TEWL). Under experimental conditions IALUSET VITAL® significantly reduced severity, as shown SCORAD index, revealed be effective alleviating most common signs AD, suppressing itch improving moisturization, have good safety profile, being well-tolerated patients. However, statistically significant differences between active vehicle group were not found other analyzed, likely because basic formulation guarantees emollient properties addition haenkei ingredients results great increase effectiveness.